Scientists have genetically modified tobacco plants to knock out a gene that helps turns nicotine into one of the carcinogens in cured tobacco.
The Philip Morris-funded North Carolina State researchers say the work could lead to less cancer-causing chewing tobacco. In large-scale field trials, they compared the levels of N-nitrosonornicotine, a chemical known as NNN, between GM tobacco plants and a control group. They found a six-fold decrease in NNN and a 50 percent overall drop in a whole class of nasty substances known as tobacco-specific nitrosamines.
The new work appears in Plant Biotechnology Journal. The researchers do not state how much the use of the tobacco could reduce the health risks from chewing tobacco. Given the other 15-odd carcinogenic substances present even in chew, they do note that the best way to avoid cancer from nicotine is not to use it.